Summer School on Epilepsy     
July 22th August 3rd - 2002
Advanced International Course - Bridging basic with clinical epileptology
21 July-4 August 2002 - San Servolo, Venice, Italy
Sponsored by ILAE, ISNV and NATO

Registration deadline: March 31st 2002.

The compiled form should be faxed (+39 02 70600775) or e-mailed (decurtis@istituto-besta.it or decurtis.besta@interbusiness.it) to the Organizing Committee of the Course.

First Name ………………………….………. Last Name …………………………….……………
Degree……….…Present.position…………………………Department…………………………
Institution/Company …………………………………………………………………………………………
Address………………………………………………………………………….…………………………………….
City …………………………….. Country ……………………….………….. Zip: ………………………
Tel …………………………… Fax.…..……………………… E-mail ………………….………………….
A curriculum vitae with the list of publication and a 200-word abstract of the poster or case report presentation should be sent with the registration form.

Registration and accomodation fee (800 Euros) should be made payable as money order to
SCUOLA INTERNAZIONALE DI SCIENZE NEUROLOGICHE - SAN.SERVOLO, VENEZIA, ITALY
BANCA COMMERCIALE DI VENEZIA - FILIALE S. BARTOLOMEO, VENEZIA, ITALY
ACCOUNT NUMBER 4798110157; ABI CODE 3069; CAB CODE 2045; SWIFT CODE BCITITMM905
Please, indicate the following causal: "Registration fee for Advanced International Course, July 21st-August 4th 2002, San Servolo, Venice". A copy of the recepit of the money order should be sent by fax to Dr. Marco de Curtis +39 02 70600775.

Funds will be available to support a considerable number of applicants. Please, fill the lines below:
I am interested ….…. or not interested ….. in receiving a fellowship for: registration/accommodation expenses …… Travel expenses……
both registration/accommodation and traveling expenses……
Signature………………………………………………………………………..date………………………..
Bursaries will be allocated by the Organizing Committee within one month after the registration deadline.

PROGRAM

July 22th - Introduction to epilepsies - Focus on the general criteria for classification and diagnosis of epilepsies and on research tools available for the study of epilepsies and epileptogenesis.
a.m. -830-10.30 nosology of epilepsies Tassinari and Engel
-11-13 diagnostic tools Shorvon and Lopes Da Silva
p.m. -14-16 models of epilepsies and epileptogenesis Moshe and Chepurnov
-16.30-18.30 neurobiological methods in epileptogenesis Avoli and Shandra

July 23th - Nature and nurture: the dynamic process of epileptogenesis - Focus on the basic mechanisms that subtend the development of epileptiform activity in animal models and in humans, and the action of antiepileptic drugs.
a.m. -8.30 - 10.30 cellular networks relevant for epileptogenesis Gutnick and de Curtis
-11-13. genetic background and phenotypic expression Mrabet and Noebels
p.m. -14-16 synaptic and non-synaptic communication in epilepsy Heinemann and Mody
-16.30-18.30 principles of pharmacological therapy Perucca and Wolf

July 24th - Specific epileptic syndromes -
a.m. Mesial temporal lobe epilepsy
-8.30-9.30 definition and clinical presentation Engel
-9.30-10.30 neurobiology of hippocampal sclerosis Ben Ari
-11-12. developmental aspects Moshe
-12-13. surgical treatment Francione
p.m. Development and epileptic encephalopathies
-14-15 concepts on epileptic encephalopathies Bernardo Dalla Bernardina
-15-16 Brain development Spreafico
-16.30-17.30 epileptic encephalopathy of infancy Plouin
- 17.30-18.30 epileptic encephalopathies of childhood Vigevano

July 25th
a.m -Idiopathic epilepsies
-8.30-9.30 Epilepsy as channellopathy Avanzini
-9.30-10.30 Genetics of idiopathic epilepsies Zara
-11-12 Reflex epilepsies Wolf
-12-13 Clinical forms Michelucci
p.m. -14-15 Cortex versus thalamus in generalized epilepsies Steriade
-15-16 Criptogenic versus idiopathic forms Dalla Bernardina
-16.30- 17.30 Interictal versus ictal paroxismal activity Tassinari

July 26th - Practical course - Didactic and interactive material will be illustrated: 1) microscopes for analysis of epileptic tissue samples (Spreafico and TBD); 2) virtual set-ups to simulate electrophysiological experiments (Constance Hammond and Istvan Mody); 3) video and video-EEG material from animal models and humans (Plouin, Avanzini and Halasz); 4) imaging material (MRI, PET etc; Shorvon, Engel and Francione); 5) use of information technologies and database consultation (Zara and TBD), 6) methods for the signal processing and analysis (Lopes Da Silva, Panzica and deCurtis).

The material will be available for consultation from the 27th to the 1st of August.
a.m. - 8.30-10.30 practical session
-10.45-12.45 practical session
p.m. - 14-16 practical session
- 16.15-18.15 practical session

July 27th - Practical course
a.m. - 8.30-10.30 practical session
-10.45-12.45 practical session
p.m. - Formation of working-groups and tutor assignation - Each group will be assigned a research project to be developed during the course. For each project, basic and clinical aspects will have to be developed to promote the interactions between the students with different backgrounds. Each group will be couched by two tutors and will have free access to didactic material and to 20 PCs connected to the web. The group supervisor and the other tutors will be available for the following days for individual and open tutorials. Each group will present the research project at the end of the course.
- Working group activity and consultation of didactic material

July 28th - Day off

July 29th - Tutorial and individual/team practical part
a.m. - 830-10 Journal club - public discussion of a scientific manuscript lead by one or more students
- 10-12 Working group tutorial - between each group and tutors
- 12-13 Open tutorial - open discussion of issues related to the development of the student work
p.m. - Working group activity and consultation of didactic material

July 30th - Tutorial and individual/team practical part
a.m. - 8.30-10 Tutorial - interim progress report of working groups
- 10-12 Working group tutorial - between each group and tutors
- 12-13 Open tutorial - open discussion of issues related to the development of the student work
p.m. - Working group activity and consultation of didactic material

July 31st - Tutorial and individual/team practical part
a.m. - 8.30-10 Case reports - lead by one or more students
- 10-12 Working group tutorial - between each group and tutors
- 12-13 Open tutorial - open discussion of issues related to the development of the student work
p.m. - Working group activity and consultation of didactic material

August 1st - Tutorial and individual/team practical part
a.m. - 8.30-10 Journal club - public discussion of a scientific manuscript lead by one or more students
- 10-12 Working group tutorial - between each group and tutors
- 12-13 Open tutorial - open discussion of issues related to the development of the student work
p.m. - Working group activity and consultation of didactic material

August 2 nd - Working group presentation- The project will be presented by each group. The work will discussed and criticized by the participants (students, lecturers and tutors).

a.m. -8.30-10.30 1st Working group
-11-13 2nd Working group
p.m. - 14.30-16.30 3rd Working group
- 17 general discussion
August 3 rd - Working group presentation
a.m. - 8.30-10.30 4st Working group
- 11-13 5nd Working group
p.m. - 14.30-16.30 6th Working group
- 17 general discussion